Highlights
Heterogeneousformsofitchunderlieatopicdermatitis
Basophilspromoteamastcell-independentformofIgE-mediateditch
Allergen-stimulatedbasophilsreleaseleukotrieneC4andinteractwithsensorynerves
LeukotrieneC4-CysLTR2neuronalsignalingmediatesacuteitchflares
Summary
Itchisanevolutionarilyconservedsensationthatfacilitatesexpulsionofpathogensandnoxiousstimulifromtheskin.However,inorganfailure,cancer,andchronicinflammatorydisorderssuchasatopicdermatitis(AD),itchbe